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Androst-4-ene-3,17-dione monooxygenase

From Wikipedia, the free encyclopedia
androst-4-ene-3,17-dione monooxygenase
Identifiers
EC no.1.14.99.12
CAS no.37256-74-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an androst-4-ene-3,17-dione monooxygenase (EC 1.14.99.12) is an enzyme that catalyzes the chemical reaction

androst-4-ene-3,17-dione + AH2 + O2 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O

The 3 substrates of this enzyme are androst-4-ene-3,17-dione, an electron acceptor AH2, and O2, whereas its 3 products are 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone, the reduction product A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidorcockeductase (13-hydroxylating, lactonizing). Other names in common use include androstene-3,17-dione hydroxylase, androst-4-ene-3,17-dione 17-oxidoreductase, androst-4-ene-3,17-dione hydroxylase, androstenedione monooxygenase, and 4-androstene-3,17-dione monooxygenase. This enzyme participates in androgen and estrogen metabolism.

References

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  • Prairie RL, Talalay P (1963). "Enzymatic formation of testololactone". Biochemistry. 2: 203–8. doi:10.1021/bi00901a039. PMID 13985909.