Jump to content

4-hydroxy-4-methyl-2-oxoglutarate aldolase

From Wikipedia, the free encyclopedia
4-hydroxy-4-methyl-2-oxoglutarate aldolase
Identifiers
EC no.4.1.3.17
CAS no.37290-65-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme 4-hydroxy-4-methyl-2-oxoglutarate aldolase (EC 4.1.3.17) catalyzes the chemical reaction

4-hydroxy-4-methyl-2-oxoglutarate 2 pyruvate

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming). Other names in common use include pyruvate aldolase, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, 4-hydroxy-4-methyl-2-ketoglutarate aldolase, and 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase. This enzyme participates in benzoate degradation via hydroxylation and c5-branched dibasic acid metabolism.

References

[edit]
  • Maruyama K (February 1983). "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". J. Biochem. 93 (2). Tokyo: 557–65. PMID 6841353.
  • Sharma ML, Kaul SM, Shukla OP (1984). "Metabolism of 2-hydroxypyridine by Bacillus brevis (INA)". Biol. Membr. 9: 43–52.
  • Tack BF, Chapman PJ, Dagley S (1972). "Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase". J. Biol. Chem. 247 (20): 6444–9. PMID 5076765.
  • Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302.