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6-oxocamphor hydrolase

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6-oxocamphor hydrolase
Identifiers
EC no.3.7.1.18
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6-oxocamphor hydrolase (EC 3.7.1.18, OCH, camK (gene)) is an enzyme with systematic name bornane-2,6-dione hydrolase.[1][2][3] This enzyme catalyses the following chemical reaction

bornane-2,6-dione + H2O [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate

This enzyme is isolated from Rhodococcus sp.

References

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  1. ^ Grogan G, Roberts GA, Bougioukou D, Turner NJ, Flitsch SL (April 2001). "The desymmetrization of bicyclic beta -diketones by an enzymatic retro-Claisen reaction. A new reaction of the crotonase superfamily". The Journal of Biological Chemistry. 276 (16): 12565–72. doi:10.1074/jbc.M011538200. PMID 11278926.
  2. ^ Whittingham JL, Turkenburg JP, Verma CS, Walsh MA, Grogan G (January 2003). "The 2-A crystal structure of 6-oxo camphor hydrolase. New structural diversity in the crotonase superfamily". The Journal of Biological Chemistry. 278 (3): 1744–50. doi:10.1074/jbc.M211188200. PMID 12421807.
  3. ^ Leonard PM, Grogan G (July 2004). "Structure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-alpha-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homolog". The Journal of Biological Chemistry. 279 (30): 31312–7. doi:10.1074/jbc.M403514200. PMID 15138275.
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