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Summary

Description
English: After initial binding of the ACE2 receptor, SARS-CoV spike is proteolytically activated and enzymatically cleaved at the S1/S2 level. S1 than dissociates from S2 and the truncated 2 subunit of the Spike protein facilitates fusion of viral and cellular membranes.
Date
Source

Rossi, G.A., Sacco, O., Mancino, E. et al. Differences and similarities between SARS-CoV and SARS-CoV-2: spike receptor-binding domain recognition and host cell infection with support of cellular serine proteases. Infection 48, 665–669 (2020).

https://doi.org/10.1007/s15010-020-01486-5
Author Giovanni A. Rossi, Oliviero Sacco, Enrica Mancino, Luca Cristiani, and Fabio Midulla
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Captions

After initial binding of the ACE2 receptor, SARS-CoV spike is proteolytically activated and enzymatically cleaved at the S1/S2 level.

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31 July 2020

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bd5496842a4f13930659230bafe3137d8661d834

92,860 byte

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Date/TimeThumbnailDimensionsUserComment
current08:01, 1 February 2021Thumbnail for version as of 08:01, 1 February 20211,502 × 612 (91 KB)Guest2625Uploaded a work by Giovanni A. Rossi, Oliviero Sacco, Enrica Mancino, Luca Cristiani, and Fabio Midulla from Rossi, G.A., Sacco, O., Mancino, E. et al. Differences and similarities between SARS-CoV and SARS-CoV-2: spike receptor-binding domain recognition and host cell infection with support of cellular serine proteases. Infection 48, 665–669 (2020). https://doi.org/10.1007/s15010-020-01486-5 with UploadWizard

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