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Summary

Description
English: Albendazole is metabolized into R(+)-albendazole sulfoxide and S(-)-albendazole sulfoxide. Both are metabolized to albendazole sulfone.
Date
Source Own work
Author Prof. Squirrel
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SVG development
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This structural formula was created with Adobe Illustrator.

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Made using the chemfig package in LaTex:

 
This W3C-unspecified vector image was created with LaTeX.

}

\renewcommand{\familydefault}{\sfdefault}

\begin{document} \hspace{-1.5in} \schemestart % ALBENDAZOLE @c1 \chemname{

   \chemfig{
   -[:30] -[:-30] -[:30]S -[:-30] 
   *6( =  %bottom
       - 
       = *5(-N
            = ( -\chembelow{N}{H} -[:60]( =[:120]O ) -O -[:60] )
            -\chemabove{N}{H}  
            -
            -
            )
       - %top
       =
       -
       )
   }

}{albendazole} \arrow(.mid east--.mid west){<->[FMO][]}[30,2] % alb -> + alb sulfoxide \setlewis{}{}{magenta} %ALBENDAZOLE SULFOXIDE (+) \chemname{

   \chemfig{
   -[:30] -[:-30] -[:30]S ( <[:120,1.25,,,,magenta]\color{magenta}{O} ) ( <:[:50,1.25,,,,magenta]\color{white}{\Lewis{1:,.}} ) -[:-30] 
   *6( =  %bottom
       - 
       = *5(-N
            = ( -\chembelow{N}{H} -[:60]( =[:120]O ) -O -[:60] )
            -\chemabove{N}{H}  
            -
            -
            )
       - %top
       =
       -
       )
   }

}{R(+)-albendazole sulfoxide} \arrow(@c1.mid east--.mid west){<->[][CYP]}[-30,2] % alb -> - alb sulfoxide \arrow(@c2.east--@c4.west){->[\sf{CYP}]}[30,2] \setlewis{}{}{magenta} %ALBENDAZOLE SULFOXIDE (-) \chemname {

   \chemfig{
   -[:30] -[:-30] -[:30]S ( <[:120,1.25,,,,magenta]\color{white}{\Lewis{3:,.}} ) ( <:[:50,1.25,,,,magenta]\color{magenta}{O} ) -[:-30] 
   *6( =  %bottom
       - 
       = *5(-N
            = ( -\chembelow{N}{H} -[:60]( =[:120]O ) -O -[:60] )
            -\chemabove{N}{H}  
            -
            -
            )
       - %top
       =
       -
       )
   }

}{S(-)-albendazole sulfoxide} \arrow(.east--.west){->[][CYP]}[30,2] %ALBENDAZOLE SULFONE \chemname {

   \chemfig{
   -[:30] -[:-30] -[:30]S ( =[:60,,,,,magenta]\color{magenta}{O} )( =[:120,,,,,magenta]\color{magenta}{O} ) -[:-30] 
   *6( =  %bottom
       - 
       = *5(-N
            = ( -\chembelow{N}{H} -[:60]( =[:120]O ) -O -[:60] )
            -\chemabove{N}{H}  
            -
            -
            )
       - %top
       =
       -
       )
   }

}{albendazole sulfone} \schemestop \end{document} }}

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Public domain This image of a simple structural formula is ineligible for copyright and therefore in the public domain, because it consists entirely of information that is common property and contains no original authorship.

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7 August 2017

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Date/TimeThumbnailDimensionsUserComment
current04:16, 8 August 2017Thumbnail for version as of 04:16, 8 August 2017622 × 179 (65 KB)Prof. SquirrelUser created page with UploadWizard

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