Jump to content

Acyl-homoserine-lactone acylase

From Wikipedia, the free encyclopedia
Acyl-homoserine-lactone acylase
Identifiers
EC no.3.5.1.97
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Acyl-homoserine-lactone acylase (EC 3.5.1.97, acyl-homoserine lactone acylase, AHL-acylase, AiiD, N-acyl-homoserine lactone acylase, PA2385 protein, quorum-quenching AHL acylase, quorum-quenching enzyme, PvdQ, QuiP) is an enzyme with systematic name N-acyl-L-homoserine-lactone amidohydrolase.[1][2] This enzyme functions as a quorum quencher by catalysing the following chemical reaction

an N-acyl-L-homoserine lactone + H2O L-homoserine lactone + a carboxylate

Acyl homoserine lactones (AHLs) are produced by a number of bacterial species .

References

[edit]
  1. ^ Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Cámara M, Williams P, Quax WJ (March 2006). "Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1". Infection and Immunity. 74 (3): 1673–82. doi:10.1128/iai.74.3.1673-1682.2006. PMC 1418629. PMID 16495538.
  2. ^ Lin YH, Xu JL, Hu J, Wang LH, Ong SL, Leadbetter JR, Zhang LH (February 2003). "Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes". Molecular Microbiology. 47 (3): 849–60. doi:10.1046/j.1365-2958.2003.03351.x. PMID 12535081.
[edit]