Jump to content

Calbindin 1

From Wikipedia, the free encyclopedia

CALB1
Identifiers
AliasesCALB1, CALB, D-28K, calbindin 1
External IDsOMIM: 114050; MGI: 88248; HomoloGene: 21026; GeneCards: CALB1; OMA:CALB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004929
NM_001366795

NM_009788

RefSeq (protein)

NP_004920
NP_001353724

NP_033918

Location (UCSC)Chr 8: 90.06 – 90.1 MbChr 4: 15.88 – 15.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calbindin 1 is a protein that in humans is encoded by the CALB1 gene. It belongs to the calbindin family of calcium-binding proteins, along with calretinin (CALB2). [5]

Function

[edit]

The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability.[6] This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015].

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104327Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028222Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Calbindin 1". Retrieved 2018-10-04.
  6. ^ Noble JW, Almalki R, Roe SM, Wagner A, Duman R, Atack JR (October 2018). "The X-ray structure of human calbindin-D28K: an improved model". Acta Crystallographica Section D. 74 (Pt 10): 1008–1014. Bibcode:2018AcCrD..74.1008N. doi:10.1107/s2059798318011610. PMC 6173056. PMID 30289411.

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.