Jump to content

dTDP-galactose 6-dehydrogenase

From Wikipedia, the free encyclopedia
DTDP-galactose 6-dehydrogenase
Identifiers
EC no.1.1.1.186
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a dTDP-galactose 6-dehydrogenase (EC 1.1.1.186) is an enzyme that catalyzes the chemical reaction

dTDP-D-galactose + 2 NADP+ + H2O dTDP-D-galacturonate + 2 NADPH + 2 H+

The 3 substrates of this enzyme are dTDP-D-galactose, NADP+, and H2O, whereas its 3 products are dTDP-D-galacturonate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-D-galactose:NADP+ 6-oxidoreductase. This enzyme is also called thymidine-diphosphate-galactose dehydrogenase. This enzyme participates in nucleotide sugars metabolism.

References

[edit]
  • Katan R, Avigad G (1966). "NADP dependent oxidation of TDP-glucose by an enzyme system from sugar beets". Biochem. Biophys. Res. Commun. 24 (1): 18–24. doi:10.1016/0006-291X(66)90403-7. PMID 4381717.