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DUF3577 RNA motif

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DUF3577
Consensus secondary structure and sequence conservation of DUF3577 RNA
Identifiers
SymbolDUF3577
RfamRF02954
Other data
RNA typeCis-reg
SOSO:0005836
PDB structuresPDBe

The DUF3577 RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] DUF3577 motifs are found in the organism Cardiobacterium valvarum and metagenomic sequences from unknown organisms.

DUF3577 motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. Most of these genes are not classified as encoding conserved protein domains. However, some encode the DUF3577 or DUF39 domain. The functions of these domains are not known. Many DUF3577 RNAs are located 5′ to Rho-independent transcription terminators, which, in turn, are 5′ to the start codon of the downstream gene. These transcription terminators could play a role in the regulatory function of the RNA, although transcription terminators are also often found 3′ to small RNAs that are transcribed independently from downstream genes.

References

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  1. ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.