Jump to content

Draft:Alex Kentsis

From Wikipedia, the free encyclopedia
  • Comment: Well done on creating the draft, and it may potentially meet the relevant requirements (including WP:GNG, WP:ANYBIO, WP:NPROF) but presently it is not clear that it does.
    As you may know, Wikipedia's basic requirement for entry is that the subject is notable. Essentially subjects are presumed notable if they have received significant coverage in multiple published secondary sources that are reliable, intellectually independent of each other, and independent of the subject. To properly create such a draft page, please see the articles ‘Your First Article’, ‘Referencing for Beginners’ and ‘Easier Referencing for Beginners’.
    Please note that many of the references are not from sources that are considered reliable for establishing notability as defined. There are far too many references to articles written by Kentsis rather than about Kentsis.
    Please note that many of the references are not formatted correctly (see Introduction to referencing with VisualEditor and Wikipedia’s Manual of Style for help).
    Additionally, the draft tends to read too much like a CV, which Wikipedia is not.
    Also, if you have any connection to the subject, including being paid, you have a conflict of interest that you must declare on your Talk page (to see instructions on how to do this please click the link).
    Please familiarise yourself with these pages before amending the draft. If you feel you can meet these requirements, then please make the necessary amendments before resubmitting the page. It would help our volunteer reviewers by identifying, on the draft's talk page, the WP:THREE best sources that establish notability of the subject.
    It would also be helpful if you could please identify with specificity, exactly which criteria you believe the page meets (eg "I think the page now meets WP:NPROF criteria #3, because XXXXX").
    Once you have implemented these suggestions, you may also wish to leave a note for me on my talk page and I would be happy to reassess. As I said, I do think this draft has potential so please do persevere. Cabrils (talk) 02:40, 15 October 2024 (UTC)

Alex Kentsis

[edit]

Alex Kentsis (born Oleg Kentsis, 1975) is a Jewish-American scientist and physician at the Memorial Sloan Kettering Cancer Center and Weill Medical College of Cornell University, known for his contributions to understanding biological self-organization, protein folding, cell signaling, and cancer therapeutics.

Education and Career

[edit]

Kentsis received his Bachelor’s degree (AB) in Biological Sciences and Master’s degree (SM) in Biochemistry from the University of Chicago. He went on to earn his Doctor of Medicine (MD) and Doctor of Philosophy (PhD) in Biophysics from the Mount Sinai School of Medicine of New York University (now Icahn School of Medicine at Mount Sinai). He completed his clinical training in pediatrics at the Boston Children’s Hospital and pediatric hematology-oncology at the Dana-Farber Cancer Institute at the Harvard Medical School.

In 2013, he joined the faculty of the Memorial Sloan Kettering Cancer Center as an assistant member and assistant professor, where he is currently Member and Professor of Pediatrics, Pharmacology, Physiology & Biophysics, and founding Director of the Tow Center for Developmental Oncology.

Research

[edit]

As a student with Tobin Sosnick, Kentsis contributed to studies of protein folding, including effects of hydration now used in molecular design.[1] As a student with Katherine Borden, Kentsis used protein engineering approaches to investigate cellular scaffolds to define a distinct mechanism of protein self-assembly relevant to various physiological processes.[2][3] His work on the promyelocytic leukemia (PML) nuclear body supported the development of ribavirin as potential cancer therapy.[4]  

Kentsis has advocated for the use of biological mass spectrometry and proteomics for the discovery of disease biomarkers and therapeutic targets.[5][6][7][8] His work with Thomas Look investigated the mechanisms of autocrine receptor tyrosine kinase signaling in acute myeloid leukemias,[9] contributing to the general mechanism of adaptive cancer therapy resistance by feedback activation, alongside similar studies by Neal Rosen, Todd Golub, and Jeff Engelman. Subsequently, his laboratory has elucidated genetic and epigenetic mechanisms of chemotherapy resistance and therapies targeting oncogenic transcription factors.[10][11]  

Since 2015, Kentsis’ research in childhood cancer biology identified developmental mechanisms of site-specific oncogenic mutations.[12][13][14] This established the concept of developmental mutators, proposing a unified theory of why certain cancers develop in young people.[15][16]

As of 2024, Kentsis has authored over 120 publications, with over 8000 citations.

Awards and Honors

[edit]

Scholar Award, American Society of Hematology (2014)[17]

Scholar Award, Rita Allen Foundation (2016)[18]

Clinical Investigator Award, Damon Runyon Cancer Research Foundation (2016)[19]

St. Baldrick's Foundation Robert J. Arceci Innovation Award (2018)[20]

Young Investigator Award, Society for Pediatric Research (2018)[21]

Elected Member, American Society for Clinical Investigation (2018)[22]

Scholar Award, Leukemia and Lymphoma Society (2019)[23]

Pershing Square Sohn Prize (2019)[24]

Personal Life

[edit]

Kentsis was born in 1975 in Kishinev, Moldavian SSR (now Chișinău, Moldova) when it was part of the Soviet Union. Escaping antisemitism, his family emigrated to USA in 1989. He is married to Nina Kentsis (née Shapiro), a researcher and writer,[25] and they have two children.  

References

[edit]
  1. ^ Kentsis, Alex; Sosnick, Tobin R. (1998-10-01). "Trifluoroethanol Promotes Helix Formation by Destabilizing Backbone Exposure: Desolvation Rather than Native Hydrogen Bonding Defines the Kinetic Pathway of Dimeric Coiled Coil Folding". Biochemistry. 37 (41): 14613–14622. doi:10.1021/bi981641y. ISSN 0006-2960. PMID 9772190.
  2. ^ Kentsis A, Gordon RE, Borden KL. "Control of biochemical reactions through supramolecular RING domain self-assembly". Roceedings of the National Academy of Science U S A. 99 (24): 15404–9. doi:10.1073/pnas.252510999 (inactive 2024-10-15).{{cite journal}}: CS1 maint: DOI inactive as of October 2024 (link) CS1 maint: multiple names: authors list (link)
  3. ^ Kentsis A, Gordon RE, Borden KL. "Self-assembly properties of a model RING domain". Proceedings of the National Academy of Science U S A. 99 (2): 667–72. doi:10.1073/pnas.012601399 (inactive 2024-10-15). PMID 11792829.{{cite journal}}: CS1 maint: DOI inactive as of October 2024 (link) CS1 maint: multiple names: authors list (link)
  4. ^ Kentsis A, Topisirovic I, Culjkovic B, Shao L, Borden KL (2004). "Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap". Proceedings of the National Academy of Science U S A. 101 (52): 18105–10. doi:10.1073/pnas.0407401101. PMC 526201. PMID 15534199.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ Kentsis, Alex; Monigatti, Flavio; Dorff, Kevin; Campagne, Fabien; Bachur, Richard; Steen, Hanno (2009-09-01). "Urine proteomics for profiling of human disease using high accuracy mass spectrometry". Proteomics. Clinical Applications. 3 (9): 1052–1061. doi:10.1002/prca.200900008. ISSN 1862-8346. PMC 2994589. PMID 21127740.
  6. ^ Cifani, Paolo; Kentsis, Alex (November 2017). "High Sensitivity Quantitative Proteomics Using Automated Multidimensional Nano-flow Chromatography and Accumulated Ion Monitoring on Quadrupole-Orbitrap-Linear Ion Trap Mass Spectrometer". Molecular & Cellular Proteomics : MCP. 16 (11): 2006–2016. doi:10.1074/mcp.RA117.000023. ISSN 1535-9476. PMC 5672005. PMID 28821601.
  7. ^ Cifani, Paolo; Dhabaria, Avantika; Chen, Zining; Yoshimi, Akihide; Kawaler, Emily; Abdel-Wahab, Omar; Poirier, John T.; Kentsis, Alex (2018-11-02). "ProteomeGenerator: A Framework for Comprehensive Proteomics Based on de Novo Transcriptome Assembly and High-Accuracy Peptide Mass Spectral Matching". Journal of Proteome Research. 17 (11): 3681–3692. doi:10.1021/acs.jproteome.8b00295. ISSN 1535-3893. PMC 6727203. PMID 30295032.
  8. ^ Cifani P, Kentsis A (2022). "Quantitative Cell Proteomic Atlas: Pathway-Scale Targeted Mass Spectrometry for High-Resolution Functional Profiling of Cell Signaling". J Proteome Res. 21 (10): 2535–2544. doi:10.1021/acs.jproteome.2c00375. PMC 9639206. PMID 36255714.
  9. ^ Kentsis, Alex; Reed, Casie; Rice, Kim L.; Sanda, Takaomi; Rodig, Scott J.; Tholouli, Eleni; Christie, Amanda; Valk, Peter J.M.; Delwel, Ruud; Ngo, Vu; Kutok, Jeffery L.; Dahlberg, Suzanne E.; Moreau, Lisa A.; Byers, Richard J.; Christensen, James G. (July 2012). "Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia". Nature Medicine. 18 (7): 1118–1122. doi:10.1038/nm.2819. ISSN 1078-8956. PMC 3438345. PMID 22683780.
  10. ^ Brown, Fiona C.; Still, Eric; Koche, Richard P.; Yim, Christina Y.; Takao, Sumiko; Cifani, Paolo; Reed, Casie; Gunasekera, Shehana; Ficarro, Scott B.; Romanienko, Peter; Mark, Willie; McCarthy, Craig; de Stanchina, Elisa; Gonen, Mithat; Seshan, Venkatraman (April 2018). "MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia". Cancer Discovery. 8 (4): 478–497. doi:10.1158/2159-8290.CD-17-1271. ISSN 2159-8274. PMC 5882571. PMID 29431698.
  11. ^ Ramaswamy, Kavitha; Forbes, Lauren; Minuesa, Gerard; Gindin, Tatyana; Brown, Fiona; Kharas, Michael G.; Krivtsov, Andrei V.; Armstrong, Scott A.; Still, Eric; de Stanchina, Elisa; Knoechel, Birgit; Koche, Richard; Kentsis, Alex (2018-01-09). "Peptidomimetic blockade of MYB in acute myeloid leukemia". Nature Communications. 9 (1): 110. Bibcode:2018NatCo...9..110R. doi:10.1038/s41467-017-02618-6. ISSN 2041-1723. PMC 5760651. PMID 29317678.
  12. ^ Henssen, Anton G.; Koche, Richard; Zhuang, Jiali; Jiang, Eileen; Reed, Casie; Eisenberg, Amy; Still, Eric; MacArthur, Ian C.; Rodríguez-Fos, Elias; Gonzalez, Santiago; Puiggròs, Montserrat; Blackford, Andrew N.; Mason, Christopher E.; de Stanchina, Elisa; Gönen, Mithat (July 2017). "PGBD5 promotes site-specific oncogenic mutations in human tumors". Nature Genetics. 49 (7): 1005–1014. doi:10.1038/ng.3866. ISSN 1061-4036. PMC 5489359. PMID 28504702.
  13. ^ Henssen, Anton G.; Reed, Casie; Jiang, Eileen; Garcia, Heathcliff Dorado; von Stebut, Jennifer; MacArthur, Ian C.; Hundsdoerfer, Patrick; Kim, Jun Hyun; de Stanchina, Elisa; Kuwahara, Yasumichi; Hosoi, Hajime; Ganem, Neil; Cruz, Filemon Dela; Kung, Andrew L.; Schulte, Johannes H. (2017-11-01). "Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors". Science Translational Medicine. 9 (414): eaam9078. doi:10.1126/scitranslmed.aam9078. ISSN 1946-6234. PMC 5683417. PMID 29093183.
  14. ^ Yamada, Makiko; Keller, Ross R.; Gutierrez, Rodrigo Lopez; Cameron, Daniel; Suzuki, Hiromichi; Sanghrajka, Reeti; Vaynshteyn, Jake; Gerwin, Jeffrey; Maura, Francesco; Hooper, William; Shah, Minita; Robine, Nicolas; Demarest, Phillip; Bayin, N. Sumru; Zapater, Luz Jubierre (2024-03-22). "Childhood cancer mutagenesis caused by transposase-derived PGBD5". Science Advances. 10 (12): eadn4649. Bibcode:2024SciA...10N4649Y. doi:10.1126/sciadv.adn4649. ISSN 2375-2548. PMC 10959420. PMID 38517960.
  15. ^ Kentsis, Alex (July 2020). "Why do young people get cancer?". Pediatric Blood & Cancer. 67 (7): e28335. doi:10.1002/pbc.28335. ISSN 1545-5009. PMC 7582786. PMID 32391946.
  16. ^ Kentsis, Alex (October 2024). "Toward a Unified Theory of Why Young People Develop Cancer". Cold Spring Harbor Perspectives in Medicine. 14 (10): a041658. doi:10.1101/cshperspect.a041658. ISSN 2157-1422. PMC 11444251. PMID 38692742.
  17. ^ "ASH Scholar Award Recipients". Retrieved October 14, 2024.
  18. ^ "Alex Kentsis". Retrieved October 14, 2024.
  19. ^ "Meet Our Scientists". Retrieved October 14, 2024.
  20. ^ "St. Baldrick's Foundation Supports Innovative Childhood Cancer Research Through One-of-a-Kind Grant" (Press release). Retrieved October 14, 2024.
  21. ^ "Awards | Funding – Society for Pediatric Research". Retrieved October 14, 2024.
  22. ^ [. https://data.the-asci.org/controllers/asci/DirectoryController.php?action=profile&entryId=501533 . https://data.the-asci.org/controllers/asci/DirectoryController.php?action=profile&entryId=501533]. Retrieved October 14, 2024. {{cite web}}: Check |url= value (help); Missing or empty |title= (help)
  23. ^ "Alex Kentsis | Leukemia and Lymphoma Society". Retrieved October 14, 2024.
  24. ^ "Alex Kentsis, MD, PhD". Retrieved October 14, 2024.
  25. ^ https://www.ninakentsis.com/. Retrieved October 14, 2024. {{cite web}}: Missing or empty |title= (help)
Retrieved from "https://en.wikipedia.org/w/index.php?title=Draft:Alex_Kentsis&oldid=1251245213"