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Draft:Methenamine/sodium salicylate

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  • Comment: Hello. Regarding the submission decline, it's very common and arguably standard on Wikipedia to have independent pages for combination drugs even if the combination drug articles are short or stubs. See many of the pages at Category:Combination drugs. Methenamine and methenamine/salicylate are also used for distinct uses (former prescription drug for prevention of UTIs, latter over-the-counter drug for symptomatic treatment of active UTIs via both components). Hence, requesting reconsideration. Thank you. 76.174.0.57 (talk) 04:18, 15 October 2024 (UTC)


Methenamine/sodium salicylate
Chemical structure of methenamine
Chemical structure of sodium salicylate
Combination of
MethenamineUrinary antiseptic and antibacterial
Sodium salicylateNonsteroidal anti-inflammatory drug (NSAID) and analgesic
Clinical data
Trade namesCystex, others
Other namesSodium salicylate/methenamine; Methenamine/salicylate; Methenamine/salicylic acid; Salicylate/methenamine; Salicylic acid/methenamine; Hexamine/sodium salicylate; Hexamine/salicylate
AHFS/Drugs.comMultum Consumer Information
Routes of
administration		Oral
ATC code
Legal status
Legal status

Methenamine/sodium salicylate, sold under the brand name Cystex among many others, is a combination drug of methenamine, a urinary antiseptic and antibacterial agent, and sodium salicylate, a nonsteroidal anti-inflammatory drug (NSAID) and analgesic, which is used in the treatment and prevention of urinary tract infection (UTI) symptoms.[1][2][3][4] It is available over-the-counter (OTC), including in the United States.[1][2][3][4] The drug is taken by mouth three times per day.[2][3][4]

Methenamine is also used by itself as a prescription drug in the prevention of recurrent UTIs.[1][5][6] Clinical data support its effectiveness for this indication.[1][5][6][7] Whereas methenamine alone is generally used as the hippuric acid or mandelic acid salt, methenamine/sodium salicylate employs methenamine as the free base.[1][3][8][4] The doses of methenamine in the over-the-counter combination formulation are lower than those of prescription methenamine.[2][1] This formulation is much less-studied than prescription methenamine and little clinical data are available to inform its use.[2][1]

Methenamine in general is an alternative to antibiotics in the treatment and prevention of UTIs and associated symptoms.[6][1] Unlike antibiotics, it has no risk of promoting bacterial resistance.[1][2][9]

Methenamine/sodium salicylate is sold under numerous different brand names, including Cystex Urinary Pain Relief, AZO Urinary Tract Defense, Uro-Pain Dual Action, CVS Antibacterial Plus Urinary Pain Relief, and many others.[10][4] Formulations additionally containing phenazopyridine, such as All-In-one UTI Emergency Kit, among other formulations with additional drugs, have also been marketed.[4]

See also

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References

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  1. ^ a b c d e f g h i Li JM, Cosler LE, Harausz EP, Myers CE, Kufel WD (February 2024). "Methenamine for urinary tract infection prophylaxis: A systematic review". Pharmacotherapy. 44 (2): 197–206. doi:10.1002/phar.2895. PMID 37986168.
  2. ^ a b c d e f Chwa A, Kavanagh K, Linnebur SA, Fixen DR (2019). "Evaluation of methenamine for urinary tract infection prevention in older adults: a review of the evidence". Ther Adv Drug Saf. 10: 2042098619876749. doi:10.1177/2042098619876749. PMC 6759703. PMID 31579504.
  3. ^ a b c d "Methenamine: Uses, Interactions, Mechanism of Action". DrugBank Online. 31 December 1993. Retrieved 11 October 2024.
  4. ^ a b c d e f "Search Results for methenamine". DailyMed. 2 February 2016. Retrieved 11 October 2024.
  5. ^ a b Kale S, Somani BK (November 2023). "The resurgence of methenamine hippurate in the prevention of recurrent UTIs in women- a systematic review". Curr Opin Urol. 33 (6): 488–496. doi:10.1097/MOU.0000000000001108. PMID 37337660.
  6. ^ a b c Lee BS, Bhuta T, Simpson JM, Craig JC (October 2012). "Methenamine hippurate for preventing urinary tract infections". Cochrane Database of Systematic Reviews. 10 (10): CD003265. doi:10.1002/14651858.CD003265.pub3. PMC 7144741. PMID 23076896.
  7. ^ Davidson SM, Brown JN, Nance CB, Townsend ML (March 2024). "Use of Methenamine for Urinary Tract Infection Prophylaxis: Systematic Review of Recent Evidence". Int Urogynecol J. 35 (3): 483–489. doi:10.1007/s00192-024-05726-2. PMID 38329493.
  8. ^ Schweizerischer Apotheker-Verein (2004). Index Nominum: International Drug Directory. Medpharm Scientific Publishers. pp. 775–776. ISBN 978-3-88763-101-7. Retrieved 11 October 2024.
  9. ^ Lo TS, Hammer KD, Zegarra M, Cho WC (May 2014). "Methenamine: a forgotten drug for preventing recurrent urinary tract infection in a multidrug resistance era". Expert Rev Anti Infect Ther. 12 (5): 549–554. doi:10.1586/14787210.2014.904202. PMID 24689705.
  10. ^ "Methenamine and sodium salicylate Uses, Side Effects & Warnings". Drugs.com. 7 November 2023. Retrieved 14 October 2024.
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