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Endogenous retrovirus group V member 2, envelope

From Wikipedia, the free encyclopedia
ERVV-2
Identifiers
AliasesERVV-2, ENVV2, HERV-V2, endogenous retrovirus group V member 2, endogenous retrovirus group V member 2, envelope
External IDsHomoloGene: 130358; GeneCards: ERVV-2; OMA:ERVV-2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001191055

n/a

RefSeq (protein)

NP_001177984

n/a

Location (UCSC)Chr 19: 53.04 – 53.05 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Endogenous retrovirus group V member 2, envelope is a protein that in humans is encoded by the ERVV-2 gene. [3]

Function

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Many human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on human chromosome 19 that has inactivating mutations in the gag and pol genes. This envelope glycoprotein gene appears to have been selectively preserved. The gene's protein product is expressed in the placenta and acts as a syncytin in Old World monkeys, but has lost the fusogenic activity in humans and other primate lineages.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000268964Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: Endogenous retrovirus group V member 2, envelope". Retrieved 2017-09-13.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.