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FBXO6

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FBXO6
Identifiers
AliasesFBXO6, FBG2, FBS2, FBX6, Fbx6b, F-box protein 6
External IDsOMIM: 605647; MGI: 1354743; HomoloGene: 9274; GeneCards: FBXO6; OMA:FBXO6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018438

NM_001163704
NM_001163705
NM_001163706
NM_001163707
NM_015797

RefSeq (protein)

NP_060908

NP_001157176
NP_001157177
NP_001157178
NP_001157179
NP_056612

Location (UCSC)Chr 1: 11.66 – 11.67 MbChr 4: 148.23 – 148.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.[5][6][7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116663Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055401Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. ^ Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (Nov 2000). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID 10945468.
  7. ^ a b "Entrez Gene: FBXO6 F-box protein 6".

Further reading

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