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Glutathione peroxidase 5

From Wikipedia, the free encyclopedia
GPX5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGPX5, HEL-S-75p, glutathione peroxidase 5, GPx-5, EGLP, GSHPx-5
External IDsOMIM: 603435; MGI: 104886; HomoloGene: 1155; GeneCards: GPX5; OMA:GPX5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001509
NM_003996

NM_010343

RefSeq (protein)

NP_001500
NP_003987

NP_034473

Location (UCSC)Chr 6: 28.53 – 28.53 MbChr 13: 21.47 – 21.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.[5][6]

GPx-5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]

References

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  1. ^ a b c ENSG00000224586 GRCh38: Ensembl release 89: ENSG00000257770, ENSG00000224586Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004344Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: glutathione peroxidase 5 (epididymal androgen-related protein)".
  6. ^ Hall L, Williams K, Perry AC, Frayne J, Jury JA (July 1998). "The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract". Biochem. J. 333 (1): 5–9. doi:10.1042/bj3330005. PMC 1219548. PMID 9639555.

Further reading

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