IH636 grape seed extract
IH636 Grape Seed Extract is a dietary supplement derived from the seeds of grapes, specifically known for its high concentration of proanthocyanidins. These compounds, a type of polyphenol, are renowned for their antioxidant properties, which may provide health benefits, including cardiovascular protection and enhanced immune function.[1]
Mechanism of Action
[edit]The bioactive compounds in IH636 grape seed extract work by neutralizing free radicals, which are unstable molecules that can damage cells and contribute to aging and various diseases. Proanthocyanidins, the main components of the extract, have been shown to inhibit oxidative stress and inflammation. By scavenging free radicals, these compounds can prevent DNA damage and support overall cellular health.[2]
Clinical Applications
[edit]Studies suggest that IH636 grape seed extract may have several health benefits:
Cardiovascular Health: The extract has been studied for its role in supporting cardiovascular health by improving blood flow, reducing blood pressure, and decreasing cholesterol levels. Its anti-inflammatory effects can help protect against the progression of cardiovascular diseases.[3]
Anticancer Properties: Preliminary studies have investigated the potential of IH636 grape seed extract in cancer prevention and treatment. Its ability to induce apoptosis and inhibit cell proliferation has shown promise, particularly in models of skin cancer and breast cancer.[4]
Neuroprotective Effects: Due to its antioxidant capabilities, IH636 grape seed extract is being explored for its potential to protect against neurodegenerative diseases such as Alzheimer's disease. Research suggests that it may help in reducing oxidative damage in the brain, which is associated with cognitive decline.[5]
Safety and Side Effects
[edit]The extract is generally considered safe when consumed in moderate amounts, with few reported side effects. However, high doses may cause gastrointestinal discomfort, including nausea and diarrhea. Individuals on blood-thinning medications should consult their healthcare provider before using IH636 grape seed extract, as it may increase the risk of bleeding.[6]
References
[edit]- ^ Bagchi, D (2002). "Protective effects of IH636 grape seed proanthocyanidin extract against oxygen radical-induced chronic pancreatitis in rats". Research Communications in Molecular Pathology and Pharmacology. 112 (3–4): 167–176. PMID 12487376.
- ^ Bagchi, M (2006). "Protective effects of grape seed proanthocyanidin extract on a variety of diseases". Free Radical Research. 40 (7): 731–739. doi:10.1080/10715760600732867. PMID 16753892.
- ^ Ray, SD (2000). "Prevention of acetaminophen-induced hepatic and renal damage by IH636 grape seed proanthocyanidin extract". Research Communications in Molecular Pathology and Pharmacology. 107 (1–2): 121–136. PMID 11444181.
- ^ Bagchi, D (2004). "Role of grape seed proanthocyanidins in health and disease". BioFactors. 22 (1–4): 197–201. doi:10.1002/biof.5520220124. PMID 15630180.
- ^ Sharma, P (2012). "Neuroprotective potential of grape seed proanthocyanidin extract in various experimental models". Acta Poloniae Pharmaceutica. 69 (4): 701–707. PMID 22757625.
- ^ Mildner-Szkudlarz, S (2020). "Polyphenols from grapevine and wine by-products: Key bioactives against various diseases". Journal of Functional Foods. 73: 104144. doi:10.1016/j.jff.2020.104144.