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LSP1

From Wikipedia, the free encyclopedia

LSP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLSP1, WP34, pp52, lymphocyte-specific protein 1, lymphocyte specific protein 1
External IDsOMIM: 153432; MGI: 96832; HomoloGene: 1750; GeneCards: LSP1; OMA:LSP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 11: 1.85 – 1.89 MbChr 7: 142.01 – 142.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene.[5][6]

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]

References

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  1. ^ a b c ENSG00000288199 GRCh38: Ensembl release 89: ENSG00000130592, ENSG00000288199Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018819Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kadiyala RK, McIntyre BW, Krensky AM (Jan 1991). "Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen". Eur J Immunol. 20 (11): 2417–23. doi:10.1002/eji.1830201109. PMID 2174784. S2CID 35829868.
  6. ^ a b "Entrez Gene: LSP1 lymphocyte-specific protein 1".

Further reading

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