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Lecithin retinol acyltransferase

From Wikipedia, the free encyclopedia
LRAT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLRAT, LCA14, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase), lecithin retinol acyltransferase
External IDsOMIM: 604863; MGI: 1891259; HomoloGene: 3483; GeneCards: LRAT; OMA:LRAT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301645
NM_004744

NM_023624

RefSeq (protein)

NP_001288574
NP_004735

NP_076113

Location (UCSC)Chr 4: 154.63 – 154.75 MbChr 3: 82.8 – 82.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.[5][6]

Function

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Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver.

Clinical significance

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Mutations in this gene have been associated with early-onset severe retinal dystrophy.[6]

LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121207Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028003Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D (Feb 1999). "Molecular and biochemical characterization of lecithin retinol acyltransferase". J Biol Chem. 274 (6): 3834–41. doi:10.1074/jbc.274.6.3834. PMID 9920938.
  6. ^ a b "Entrez Gene: LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)".
  7. ^ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. 9 (3): e90776. Bibcode:2014PLoSO...990776B. doi:10.1371/journal.pone.0090776. PMC 3946526. PMID 24608339.

Further reading

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