Jump to content

MPP1

From Wikipedia, the free encyclopedia

MPP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMPP1, AAG12, DXS552E, EMP55, MRG1, PEMP, membrane palmitoylated protein 1, MAGUK p55 scaffold protein 1
External IDsOMIM: 305360; MGI: 105941; HomoloGene: 1826; GeneCards: MPP1; OMA:MPP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166460
NM_001166461
NM_001166462
NM_002436

NM_008621

RefSeq (protein)

NP_001159932
NP_001159933
NP_001159934
NP_002427

NP_032647

Location (UCSC)Chr X: 154.78 – 154.82 MbChr X: 74.15 – 74.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

55 kDa erythrocyte membrane protein is a protein that in humans is encoded by the MPP1 gene.[5][6]

Palmitoylated membrane protein 1 is the prototype of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130830Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031402Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ruff P, Speicher DW, Husain-Chishti A (Sep 1991). "Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif". Proc Natl Acad Sci U S A. 88 (15): 6595–9. Bibcode:1991PNAS...88.6595R. doi:10.1073/pnas.88.15.6595. PMC 52133. PMID 1713685.
  6. ^ a b "Entrez Gene: MPP1 membrane protein, palmitoylated 1, 55kDa".

Further reading

[edit]