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Methylornithine synthase

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Methylornithine synthase
Identifiers
EC no.5.4.99.58
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Methylornithine synthase (EC 5.4.99.58, PylB) is an enzyme with systematic name L-lysine carboxy-aminomethylmutase.[1][2] This enzyme catalyses the conversion of L-lysine into (3R)-3-methyl-D-ornithine.

The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical enzymes.

References

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  1. ^ Gaston MA, Zhang L, Green-Church KB, Krzycki JA (March 2011). "The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine". Nature. 471 (7340): 647–50. Bibcode:2011Natur.471..647G. doi:10.1038/nature09918. PMC 3070376. PMID 21455182.
  2. ^ Quitterer F, List A, Eisenreich W, Bacher A, Groll M (February 2012). "Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis". Angewandte Chemie. 51 (6): 1339–42. doi:10.1002/anie.201106765. PMID 22095926.
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