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PDE6G

From Wikipedia, the free encyclopedia
PDE6G
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDE6G, PDEG, RP57, phosphodiesterase 6G
External IDsOMIM: 180073; MGI: 97526; HomoloGene: 1955; GeneCards: PDE6G; OMA:PDE6G - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002602
NM_001365724
NM_001365725

NM_012065

RefSeq (protein)

NP_002593
NP_001352653
NP_001352654

NP_036197

Location (UCSC)Chr 17: 81.65 – 81.66 MbChr 11: 120.34 – 120.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.[5][6][7]

Interactions

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PDE6G has been shown to interact with Beta adrenergic receptor kinase[8] and Src.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185527Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025386Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (February 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics. 6 (2): 272–83. doi:10.1016/0888-7543(90)90567-E. PMID 2155175.
  6. ^ "Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma".
  7. ^ Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L (February 2019). "Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases". Science Advances. 5 (2): eaav4322. Bibcode:2019SciA....5.4322G. doi:10.1126/sciadv.aav4322. PMC 6392808. PMID 30820458.
  8. ^ a b Wan KF, Sambi BS, Tate R, Waters C, Pyne NJ (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". The Journal of Biological Chemistry. 278 (20): 18658–63. doi:10.1074/jbc.M212103200. PMID 12624098. S2CID 25824189.

Further reading

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