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Pacer (protein)

From Wikipedia, the free encyclopedia

RUBCNL
Identifiers
AliasesRUBCNL, C13orf18, KIAA0226L, KIAA0226-like, KIAA0226 like, RUN and cysteine rich domain containing beclin 1 interacting protein like, PACER, rubicon like autophagy regulator, rubicon like autophagy enhancer
External IDsMGI: 2685590; HomoloGene: 57021; GeneCards: RUBCNL; OMA:RUBCNL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198642
NM_001374214

RefSeq (protein)

NP_941044
NP_001361143

Location (UCSC)Chr 13: 46.33 – 46.44 MbChr 14: 75.25 – 75.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pacer (also known as Rubicon-like) is a protein that in humans is encoded by the RUBCNL gene.[5] Pacer has been shown to increase cellular autophagy through regulation of PI3KC3.[6]

Pacer contains a Rubicon homology (RH) domain at its C-terminus, which mediates binding to small GTPase Rab7 when Rab7 is phosphorylated following mitochondrial damage[7].[8][9] This domain is shared with RH domain containing family members Rubicon and PLEKHM1.[10] Whereas Pacer appears to upregulate autophagic activity, Rubicon is a negative regulator of autophagy.[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102445Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034959Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "RUBCNL - Protein associated with UVRAG as autophagy enhancer - Homo sapiens (Human) - RUBCNL gene & protein". www.uniprot.org. Retrieved 2022-05-31.
  6. ^ Cheng X, Ma X, Ding X, Li L, Jiang X, Shen Z, et al. (March 2017). "Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17". Molecular Cell. 65 (6): 1029–1043.e5. doi:10.1016/j.molcel.2017.02.010. PMID 28306502.
  7. ^ Tudorica DA, Basak B, Puerta Cordova AS, Khuu G, Rose K, Lazarou M, et al. (July 2024). "A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy". The Journal of Cell Biology. 223 (7). doi:10.1083/jcb.202309015. PMC 11090050. PMID 38728007.
  8. ^ "RUBCNL - Protein associated with UVRAG as autophagy enhancer - Homo sapiens (Human) - RUBCNL gene & protein". www.uniprot.org. Retrieved 2022-05-31.
  9. ^ Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, et al. (July 2020). "Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex". Proceedings of the National Academy of Sciences of the United States of America. 117 (29): 17003–17010. Bibcode:2020PNAS..11717003B. doi:10.1073/pnas.2008030117. PMC 7382272. PMID 32632011.
  10. ^ a b Beltran S, Nassif M, Vicencio E, Arcos J, Labrador L, Cortes BI, et al. (March 2019). "Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis". Molecular Neurodegeneration. 14 (1): 14. doi:10.1186/s13024-019-0313-9. PMC 6437924. PMID 30917850.

Further reading

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