Jump to content

Phosphoenolpyruvate carboxykinase (diphosphate)

From Wikipedia, the free encyclopedia
Phosphoenolpyruvate carboxykinase (diphosphate)
Phosphoenolpyruvate carboxykinase (pyrophosphate) homodimer, Actinomyces israelii
Identifiers
EC no.4.1.1.38
CAS no.2598306
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Phosphoenolpyruvate carboxykinase (diphosphate) (EC 4.1.1.38) is an enzyme with systematic name diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming).[1] This enzyme catalyses the following chemical reaction

diphosphate + oxaloacetate phosphate + phosphoenolpyruvate + CO2

This enzyme also catalyses the reaction:

phosphoenolpyruvate + GTP + CO2 pyruvate + GDP.

It is transcriptionally upregulated in the liver by glucagon.

See also

[edit]

References

[edit]
  1. ^ Lochmüller H, Wood HG, Davis JJ (December 1966). "Phosphoenolpyruvate carboxytransphosphorylase. II. Crystallization and properties". The Journal of Biological Chemistry. 241 (23): 5678–91. PMID 4288896.
[edit]