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Phosphogluconate dehydratase

From Wikipedia, the free encyclopedia
phosphogluconate dehydratase
6-Phosphogluconate dehydratase monomer, Shewanella oneidensis
Identifiers
EC no.4.2.1.12
CAS no.9024-33-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
2-keto-3-deoxy-6-phosphogluconate, a product of the reaction catalysed by phosphogluconate dehydratase

The enzyme phosphogluconate dehydratase (EC 4.2.1.12) catalyzes the chemical reaction

6-phospho-D-gluconate 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-Dgluconate hydro-lyase. This enzyme participates in the Entner–Doudoroff pathway.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.

References

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  • MELOCHE HP, WOOD WA (1964). "The Mechanism of 6-Phosphogluconic Dehydrase". J. Biol. Chem. 239 (10): 3505–10. doi:10.1016/S0021-9258(18)97751-3. PMID 14245409.