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RNF19A

From Wikipedia, the free encyclopedia
RNF19A
Identifiers
AliasesRNF19A, RNF19, ring finger protein 19A, RBR E3 ubiquitin protein ligase
External IDsOMIM: 607119; MGI: 1353623; HomoloGene: 8501; GeneCards: RNF19A; OMA:RNF19A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001280539
NM_015435
NM_183419
NM_001353837
NM_001353838

NM_013923
NM_001357631

RefSeq (protein)

NP_001267468
NP_056250
NP_904355
NP_001340766
NP_001340767

NP_038951
NP_001344560

Location (UCSC)Chr 8: 100.26 – 100.34 MbChr 15: 36.24 – 36.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.[5][6][7]

The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies (LBs), neuronal inclusions characteristic of Parkinson's disease (PD). This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript variants encoding the same protein have been reported.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000034677Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022280Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G (Mar 2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem Biophys Res Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
  6. ^ Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
  7. ^ a b "Entrez Gene: RNF19 ring finger protein 19".

Further reading

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