Jump to content

TESK1

From Wikipedia, the free encyclopedia

TESK1
Identifiers
AliasesTESK1, testis-specific kinase 1, testis associated actin remodelling kinase 1
External IDsOMIM: 601782; MGI: 1201675; HomoloGene: 4577; GeneCards: TESK1; OMA:TESK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006285
NM_001318230

NM_011571

RefSeq (protein)

NP_001305159
NP_006276

NP_035701

Location (UCSC)n/aChr 4: 43.44 – 43.45 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.[4][5]

Function

[edit]

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.[5]

Interactions

[edit]

TESK1 has been shown to interact with YWHAB[6] and SPRY4.[7]

References

[edit]
  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028458Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Toshima J, Ohashi K, Okano I, Nunoue K, Kishioka M, Kuma K, Miyata T, Hirai M, Baba T, Mizuno K (December 29, 1995). "Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells". J. Biol. Chem. 270 (52): 31331–7. doi:10.1074/jbc.270.52.31331. PMID 8537404.
  5. ^ a b "Entrez Gene: TESK1 testis-specific kinase 1".
  6. ^ Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.
  7. ^ Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

Further reading

[edit]