Talk:Pitolisant

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Pitolisant.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Bad citation practice

In "History", Reference 5 is cited at the end of almost every sentence. This is bad citing practice and the text reads very unscientific overall.

Conflicting sources for pharmacology of pitolisant

The inverse agonistic property of pitolisant at h3 is well established, but secondary actions at sigma, d3, and 5ht2a are less extensively characterised. I have cited an FDA review as opposed to individual primary studies as there are some conflicting results in the primary literature. The FDA review does not state its rationale for the designation of pitolisant as an antagonist to all of the aforementioned sites. I'm not qualified to understand how the reviewers may have weighed the results of these studies. If someone here is, please take a look at the cited reviews and edit my content to be less vague. I've avoided presenting information beyond my understanding.

Reviews: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/211150Orig1s000OtherR.pdf and https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/211150Orig1s000MedR.pdf Oro Temp (talk) 19:57, 28 September 2024 (UTC)[reply]