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UPF2

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UPF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUPF2, HRENT2, smg-3, UPF2 regulator of nonsense transcripts homolog (yeast), regulator of nonsense mediated mRNA decay, UPF2 regulator of nonsense mediated mRNA decay
External IDsOMIM: 605529; MGI: 2449307; HomoloGene: 6101; GeneCards: UPF2; OMA:UPF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015542
NM_080599

NM_001081132

RefSeq (protein)

NP_056357
NP_542166

NP_001074601

Location (UCSC)Chr 10: 11.92 – 12.04 MbChr 2: 5.96 – 6.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene.[5][6][7]

Function

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This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.[7] UPF2 has recently been shown to alter adult behavior via alterations in hippocampal synaptic spine density and the late long-term potentiation of neurons.[8]

Interactions

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UPF2 has been shown to interact with UPF1,[5][9][10][11][12] UPF3A[9][12] and UPF3B.[9][12][13][14]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151461Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043241Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Mendell JT, Medghalchi SM, Lake RG, Noensie EN, Dietz HC (Dec 2000). "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes". Molecular and Cellular Biology. 20 (23): 8944–57. doi:10.1128/MCB.20.23.8944-8957.2000. PMC 86549. PMID 11073994.
  6. ^ Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE (Jan 2001). "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)". Molecular and Cellular Biology. 21 (1): 209–23. doi:10.1128/MCB.21.1.209-223.2001. PMC 88795. PMID 11113196.
  7. ^ a b "Entrez Gene: UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)".
  8. ^ Notaras M, Allen M, Longo F, Volk N, Toth M, Li Jeon N, Klann E, Colak D (2019-10-21). "UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function". Molecular Psychiatry. 25 (12): 3360–3379. doi:10.1038/s41380-019-0547-5. ISSN 1476-5578. PMC 7566522. PMID 31636381. S2CID 204812259.
  9. ^ a b c Lejeune F, Li X, Maquat LE (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
  10. ^ Schell T, Köcher T, Wilm M, Seraphin B, Kulozik AE, Hentze MW (Aug 2003). "Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells". The Biochemical Journal. 373 (Pt 3): 775–83. doi:10.1042/BJ20021920. PMC 1223536. PMID 12723973.
  11. ^ Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (Sep 2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes & Development. 15 (17): 2215–28. doi:10.1101/gad.913001. PMC 312771. PMID 11544179.
  12. ^ a b c Lykke-Andersen J, Shu MD, Steitz JA (Dec 2000). "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon". Cell. 103 (7): 1121–31. doi:10.1016/S0092-8674(00)00214-2. PMID 11163187. S2CID 18417600.
  13. ^ Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  14. ^ Lykke-Andersen J (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.

Further reading

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