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USP25

From Wikipedia, the free encyclopedia
USP25
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUSP25, USP21, ubiquitin specific peptidase 25
External IDsOMIM: 604736; MGI: 1353655; HomoloGene: 8374; GeneCards: USP25; OMA:USP25 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013918

RefSeq (protein)

NP_001269970
NP_001269971
NP_037528
NP_001339489
NP_001339490

NP_038946

Location (UCSC)Chr 21: 15.73 – 15.88 MbChr 16: 76.81 – 76.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin specific peptidase 25 is a protein that in humans is encoded by the USP25 gene. [5]

Function

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Ubiquitin is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155313Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022867Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ubiquitin specific peptidase 25". Retrieved 2017-10-31.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.