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Leigh Silverton was born to Fawn Silver, an actress who made several movies including Orgy of the Dead by Ed Wood. Her maternal grandparents were international philanthropists in the USA and in Israel. Her grandfather, Victor Carter was controlling interest in Republic Pictures. He was a business turn around specialist who quadrupled the value of the company for its shareholders.(https://jewishjournal.com/old_stories/9387/). She has two full siblings, Sheri and Robin Silverton. Robin suffered from bipolar disorder and died at 53.

Silverton attended college at 15 and graduated USC Magna Cum Laude at eighteen. Her undergraduate research mentor was Perry London (https://en.wikipedia.org/wiki/Perry_Londoncross reference).

She entered graduate school with an interest in schizophrenia. She worked with Sarnoff A. Mednick https://www.google.com/search?q=sarnoff+mednick&client=safari&sca_esv=37afbf05fd6f097e&sca_upv=1&source=hp&ei=osnuZrvtEqfbkPIP-rnuyQM&iflsig=AL9hbdgAAAAAZu7Xsr1EMHjCM_N8FShcCuOv76Qc6BJu&gs_ssp=eJzj4tLP1Tcwzk0pMc0wYPTiL04systPS1PITU3Jy0zOBgCFdgmZ&oq=sarnoff%C2%A0&gs_lp=Egdnd3Mtd2l6GgIYAyIJc2Fybm9mZsKgKgIIADIFEC4YgAQyBRAAGIAEMgsQLhiABBjRAxjHATIUEC4YgAQYpgMYxwEYqAMYiwMYrwEyCBAAGIAEGIsDMg4QLhiABBioAxiaAxiLAzIFEAAYgAQyBRAAGIAEMhQQLhiABBimAxjHARioAxiLAxivATIUEC4YgAQYpgMYxwEYqAMYiwMYrwFItxdQAFiVCXAAeACQAQCYAWOgAaEFqgEBOLgBAcgBAPgBAZgCCKAC5gXCAgsQLhiABBiRAhiKBcICERAuGIAEGJECGNEDGMcBGIoFwgIQEC4YgAQY0QMYQxjHARiKBcICChAuGIAEGEMYigXCAg4QLhiABBixAxiDARiKBcICERAuGIAEGLEDGNEDGIMBGMcBwgILEAAYgAQYsQMYgwHCAgsQABiABBiRAhiKBcICDhAuGIAEGMcBGI4FGK8BwgITEC4YgAQYsQMY0QMYQxjHARiKBcICEBAuGIAEGEMYxwEYigUYrwHCAg4QLhiABBiRAhjUAhiKBcICExAuGIAEGLEDGEMYgwEY1AIYigXCAg0QLhiABBixAxhDGIoFwgIKEAAYgAQYQxiKBcICGRAuGIAEGLEDGKIFGEMYqAMYigUYiwMYnQPCAgsQABiABBixAxiLA8ICExAAGIAEGLEDGEMYgwEYigUYiwPCAg0QABiABBhDGIoFGIsDwgIUEC4YgAQYsQMYgwEYqAMYiwMYnQPCAgsQLhiABBixAxjUAsICFxAuGIAEGKYDGMcBGKgDGIsDGI4FGK8BwgIIEC4YgAQY1ALCAgoQABiABBgKGIsDmAMAkgcDNi4yoAedhgE&sclient=gws-wiz) on the high risk for schizophrenia paradigm, developing novel ways to look at the etiology of schizophrenia.

Silverton and Mednick began working on in the early eighties. The authors conducted a study in which they separated subjects into high-risk and “super-high risk” and measured the interaction between genetic risk and birthweight in its effect on ventricular-brain ratio. They found that those most vulnerable to low birthweight, a variable representing subtle birth difficulties in utero, were most likely to have early cerebral ventricular enlargement on CT-scans.(ref) At the time, the idea both that schizophrenia was a brain disease and that it could represent a gene x environment interaction was novel. This was possibly the first study to support the notion that earlier findings of brain abnormalities in schizophrenia were not only etiologically significant but related to early environmental factors (such as pregnancy and birth complications or in utero insults), and that pathogenesis was related to factors that could be prevented. A study by Cannon, Mednick, and Parnas (1989) also showed an interaction between perinatal insults (an environmental factor) and very high genetic risk for schizophrenia in determining brain deficits in schizophrenia.

Other factors associated with breaking down with schizophrenia were shown by Elaine Walker and Robert Cudeck along with Mednick to be separation for parents (even mothers with schizophrenia) if it led to institutionalization.[ref] The outcome of the High-Risk-for-Schizophrenia study showed that it was the interaction between genetics and environment that accounted for schizophrenia. It also suggested that the final common pathway to schizophrenia is expressed as a brain disease.

Before the High Risk for Schizophrenia study, a theory that poverty caused schizophrenia developed because persons with schizophrenia were found in the most impoverished regions of the city. Silverton and Mednick hypothesized, on the other hand that those with schizophrenia drifted into the lower classes as their disease caused a cognitive disability and therefore difficulty working. In a 1984 study, they found that high risk subjects matched for socioeconomic status at birth drifted into lower social classes as the result (rather than the cause) of schizophrenia [ref]

In a 2008 reassessment of the High Risk sample by Leigh Silverton and Sarnoff A. Mednick (supported by a grant to Silverton from the American Foundation for Suicide Prevention) Silverton, Mednick, Holst and John showed a very high relative rate of suicide in those at high risk for schizophrenia. They also showed that although those with schizophrenia may drift into lower social class regions, those of higher social class origins develop schizophrenia suicide at a higher rate than those from lower social classes. The authors reasoned the although schizophrenia may largely be a brain disease, the response to cognitive impairments caused by the disorder may be harder for those from a higher initial social classes and therefore higher self-expectations.[ref]

Silverton reviewed the literature and showed a genetic relationship between criminal behavior and the schizophrenia schizophrenia spectrum at a time when the concept of schizophrenia having a genetic component was costroversial (https://brill.com/edcollchap/book/9789004612426/B9789004612426_s012.xml)

Silverton created tests with Western psychological services, the best known of which is the Malingering Probability Scale. This was published (https://criminal-justice.iresearchnet.com/forensic-psychology/criminal-responsibility-assessment/malingering-probability-scale-mps/in). This was published in the mid-nineties. Research continues to be conducted on it today. The purpose was to separate malingering persons from those with genuine pathology and the test items created by Silverton were to discriminate malingering from non-malingering populations. The manual shows a series of studies she and Christian Gruber conducted. The items have born the test of time and research in a wide variety of places continues to be conducted on it today.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0447.2007.01137.x https://scholar.google.com/citations?user=qd02n-wAAAAJ&hl=en

https://brill.com/edcollchap/book/9789004612426/B9789004612426_s012.xml