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ZNF444

From Wikipedia, the free encyclopedia
ZNF444
Identifiers
AliasesZNF444, EZF-2, EZF2, ZSCAN17, zinc finger protein 444
External IDsOMIM: 607874; MGI: 1923365; HomoloGene: 10139; GeneCards: ZNF444; OMA:ZNF444 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253792
NM_018337

NM_001146024
NM_028316

RefSeq (protein)

NP_001240721
NP_060807
NP_001240721.1

n/a

Location (UCSC)Chr 19: 56.13 – 56.16 MbChr 7: 6.18 – 6.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 444 is a protein that in humans is encoded by the ZNF444 gene. [5]

Function

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This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low-density lipoprotein (Ac-LDL) (Adachi H, Tsujimoto M (2002). "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2". J Biol Chem. 277 (27): 24014–21. doi:10.1074/jbc.M201854200. PMID 11978792.). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167685Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044876Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger protein 444". Retrieved 2017-04-14.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.